Protein Details: Amiloride-sensitive sodium channel subunit alpha

Protein ID

ICDB_Pro_0622

Protein Name

Amiloride-sensitive sodium channel subunit alpha

Gene Name

SCNN1A

Organism

Bos taurus (Bovine)

Length

650 amino acids

AlphaFoldDB

AF-P55270-F1-model_v4.pdb

Function

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water; which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis; but also in airway surface liquid homeostasis; which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney; colon; lung and eccrine sweat glands. Also plays a role in taste perception.

Sequence

MKGDKPEEPGPGPEPSGPPPPTEEEEALLEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTVFWAVLWLCTFGMMYWQFGQLFGEYFSYPVSLNINLNSDKLVFPAVSICTLNPYRYKEIQEELEELDRITEQTLFDLYKYNSSKTLVAHARSRRDLREPLPHPLQRLPVPAPPHAARGVRRAGSSMRDNNPQVNRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRRRQDTSPSLEEDVLGKFIFTCRFNQDSCNEANYSHFHHPMYGNCYTFNDKNSSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHERDEPAFMDDAGFNLRPGVETSISMSKEAVDRLGGDYGDCTKNGSEVPVENLYNTKYTQQVCIHSCFQESMIKECGCAYIFYPRPDGVEFCDYRKHNSWGYCYYKLQDAFSSDRLGCFTKCRKPCSVTIYKLSASYSQWPSATSQDWVFQMLSRQNNYTIKNKRDGVAKLNIFFKELNYKSNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELIIDLLVITFLMLLRRFRSRYWSPGRGGKGTQEVASTPAASLPSSFCPHPAFFSSSPPDPAISPALSAPPPAYATLGPHPAPSGLAEASTSAHAPGEP

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in kidney and lung (at protein level)

DOI ID

10.1152/ajpcell.1995.269.3.c641; 10.1007/s00418-011-0904-1

RefSeq

NP_777023.1